PVD-06

CAT: 0013-GTR19261270-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19261270-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PVD-06 is a selective PROTAC-based degrader of PTPN2 (with a selectivity index of greater than 60-fold over PTP1B) and exhibits anticancer activity. It induces the degradation of PTPN2 through ubiquitination and proteasome-dependent pathways. PVD-06 also enhances T cell activation and amplifies IFN-γ-mediated cytotoxicity.

CAS Number

3032975-48-4

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Smiles

C (C (O) =O) (F) (F) F.FC=1C2=C (C=C (O) C1N3S (=O) (=O) NC (=O) C3) C=CC (=C2) C4=CN (CC (NCCCCCC (N[C@H] (C (=O) N5[C@H] (C (N[C@@H] (C) C6=CC=C (C=C6) C7=C (C) N=CS7) =O) C[C@@H] (O) C5) [C@] (C) (C) C) =O) =O) N=C4

Molecular Formula

C48H55F4N9O11S2

Molecular Weight

1074.13

Storage Conditions

-20°C

Notes

For research use only.

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PVD-06

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