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PROTAC ALK degrader-5

CAT: 0013-GTR19277066-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277066-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTACALK degrader-5 (Compound 17) is a potent ALKPROTAC degrader with activities of 27.4 nM against EML4-ALK and 116.5 nM against NPM-ALK. It exhibits strong antiproliferative effects on H3122 and Karpas 299 cell lines and effectively inhibits the phosphorylation of ALK and STAT3. This compound is applicable for studying ALK-driven malignancies, such as human non-small cell lung cancer and anaplastic large cell lymphoma.
CAS Number
2379672-57-6
Smiles
N#CC=1C=CC2=C (C1) NC3=C2C (=O) C=4C=C (C (=CC4C3 (C) C) N5CCN (C (=O) CNC6=CC=CC=7C (=O) N (C (=O) C67) C8C (=O) NC (=O) CC8) CC5) CC
Molecular Formula
C40H37N7O6
Molecular Weight
711.78
Storage Conditions
-20°C
Notes
For research use only.

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