RIPK1-IN-39

CAT: 0013-GTR19274785-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19274785-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

RIPK1-IN-39 (compound 2) is a potent and selective inhibitor of RIPK1 with an IC50 of 69.40 nM, exhibiting over 100-fold selectivity for RIPK1 over RIPK3 (IC50= 6946 nM) . It protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. Additionally, RIPK1-IN-39 shows neuroprotective effects in a rat middle cerebral artery occlusion (MCAO) model. This compound is applicable in acute ischemic stroke (AIS) research.

CAS Number

3065634-42-3

Smiles

C (N[C@@H] (C) C1=CC=C (F) C=C1) (=O) C=2C3=C (C=CC (=C3) C=4C=C5C (=CC4) N=C (NC (=O) C6CC6) S5) N=C (C) N2

Molecular Formula

C29H24FN5O2S

Molecular Weight

525.6

Storage Conditions

-20°C

Notes

For research use only.

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