Products for Research Use Only

CC-647

CAT: 0013-GTR19263509-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263509-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CC-647 is a molecular glue modulator targeting the Cereblon (CRBN) E3 ubiquitin ligase. It enhances the interaction between CRBN and ZBTB16, as well as its oncogenic fusion protein RARα-ZBTB16, with a half-maximal degradation concentration (DC50) of 103 nM for ZBTB16. CC-647 holds potential for studying ZBTB16-RARα related acute promyelocytic leukemia (APL) .
CAS Number
1061605-35-3
Field of Research
Pharmacology & Drug Discovery, Protein Biochemistry
Smiles
O=C1C=2C=CC=C (OC3=CC=CC (=C3) C (C) (C) C) C2C (=O) N1C4C (=O) NC (=O) CC4
Molecular Formula
C23H22N2O5
Molecular Weight
406.43
Storage Conditions
-20°C
Notes
For research use only.

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