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SD-208

CAT: 0013-GTR19161195-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161195-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SD-208 is a potent, selective TGF-β receptor I kinase (TGF-βRI) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII kinase and >20-fold over a panel of related protein kinases; inhibits the growth inhibition of TGF-beta-sensitive CCL64 cells mediated by recombinant TGF-β1 or TGF-β2 or of TGF-β-containing glioma cell supernatant with EC50 of 0.1 uM; inhibits constitutive and TGF-β–induced invasion of glioma cells, inhibits TGF-β signaling in immune effector cells; blocks TGF-β signaling in the brain and inhibits the growth of syngeneic SMA-560 experimental gliomas in vivo.
CAS Number
627536-09-8
Product Name Alternative
SD 208 | SD208
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
FC1=CC=C (Cl) C=C1C2=NC (NC3=CC=NC=C3) =C4N=CC=NC4=N2
Molecular Formula
C17H10ClFN6
Molecular Weight
352.7529
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Pteridinamine, 2- (5-chloro-2-fluorophenyl) -N-4-pyridinyl-

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Alternative Products

CatalogName
MBS131434SD-208 (SD 208; SD208)
MBS386152-01SD-208
3269/10SD 208

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