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AMG-208

CAT: 0013-GTR19164109-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164109-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM; inhibits HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM, suppresses proliferation and induces apoptosis in human tumor xenograft models.Prostate Cancer Phase 2 Clinical (In Vitro) :AMG-208 (compound 4) treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM.Pre-incubation of AMG-208 (compound 1) with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation. (In Vivo) :In male Sprague Dawley rats, AMG-208 (0.5 mg/kg i.v.) shows a high bioavailability with Cl of 0.37 L/h/kg, Vss of 0.38 L/kg and T1/2 of 1 hour.
CAS Number
1002304-34-8
Product Name Alternative
AMG208 | AMG 208
Purity
>98% (HPLC)
Solubility
DMSO: < 1 mg/mL
Smiles
COC1=CC=C2C (OCC3=NN=C4C=CC (C5=CC=CC=C5) =NN43) =CC=NC2=C1
Molecular Formula
C22H17N5O2
Molecular Weight
383.4027
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoline, 7-methoxy-4-[ (6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl) methoxy]-

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MBS384185-01AMG 208

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