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DHW-221

CAT: 0013-GTR19273344-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273344-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHW-221 is an orally active dual PI3K/mTOR inhibitor demonstrating potent inhibition at nanomolar levels across all four Class I PI3K isoforms and mTOR (PI3Kα, IC50= 0.50 nM; PI3Kβ, IC50= 1.9 nM; PI3Kγ, IC50= 1.8 nM; PI3Kδ, IC50= 0.74 nM; mTOR, IC50= 3.9 nM) . By blocking the PI3K/Akt/mTOR pathway, DHW-221 induces mitochondrial apoptosis and paraptosis (through endoplasmic reticulum stress and MAPK signaling) and causes cell cycle arrest, thereby inhibiting cell migration, invasion, and angiogenesis to exert its antitumor effects. It suppresses tumor growth in A549/Taxol and HCC827 mouse models and is applicable in research related to non-small cell lung cancer (NSCLC), colon cancer, and breast cancer.
CAS Number
2378831-21-9
Smiles
O=S (=O) (NC=1C=C (C=NC1OC) C=2C=CC=3N=CN (C4=CC=C (OCCO) C=C4) C3C2) C5=CC=C (F) C=C5F
Molecular Formula
C27H22F2N4O5S
Molecular Weight
552.55
Storage Conditions
-20°C
Notes
For research use only.

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