PF-06409577

• Description:

  PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/PF-06409577.html

• Purity:

  99.83

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(C1=CNC2=C1C=C(C3=CC=C(C4(O)CCC4)C=C3)C(Cl)=C2)O

• Molecular Formula:

  C19H16ClNO3

• Molecular Weight:

  341.79

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Cameron KO, et al. Discovery and Preclinical Characterization of 6-Chloro-5-[4- (1-hydroxycyclobutyl) phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J Med Chem. 2016 Sep 8;59 (17) :8068-81.|[2]Salatto CT, et al. Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. J Pharmacol Exp Ther. 2017 May;361 (2) :303-311.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  AMPK α1β1γ1

• CAS Number:

  1467057-23-3