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Antimalarial agent 41

CAT: 0013-GTR19262758-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262758-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity by inhibiting the malaria parasite Plasmodium falciparum, with IC50 values of 40 nM for NF54 strain and 76 nM for K1 strain. This compound acts as an inhibitor of P. falciparum phosphatidylinositol-4-kinase β (PfPI4K) and hERG channels, with IC50 values of 53 nM and 3 μM, respectively. Additionally, Antimalarial agent 41 shows cytotoxicity against CHO cells, with an IC50 of 34 μM. It can improve malaria infections and demonstrates favorable pharmacokinetic properties in mouse models.
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C19H18F3N5
Storage Conditions
-20°C
Notes
For research use only.

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