Products for Research Use Only
RegisterLogin

PROTAC sEH-degrader-3

CAT: 0013-GTR19264742-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19264742-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PROTACsEH-degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that selectively degrades cytosolic sEH without affecting sEH in peroxisomes. It degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasomal pathway, with an IC50 of 0.8 nM for hsEH. Additionally, PROTACsEH-degrader-3 inhibits endoplasmic reticulum stress, making it useful for research on diseases related to inflammation, metabolic disorders, and other conditions associated with endoplasmic reticulum stress.
CAS Number
3093413-94-3
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2OCC (NCCOCCOCCOCCOCCNC (=O) C4=CC=C (O[C@H]5CC[C@H] (NC (NC6=CC=C (OC (F) (F) F) C=C6) =O) CC5) C=C4) =O
Molecular Formula
C46H53F3N6O14
Molecular Weight
970.94
Storage Conditions
-20°C
Notes
For research use only.

Related Products

CatalogName
GTR19263180-01PROTAC sEH degrader-2
GTR19239001-01PROTAC sEH-degrader-1
GTR19225039-01PROTAC FKBP Degrader-3
GTR19237799-01PROTAC GPX4 degrader-3
GTR19222237-01PROTAC IRAK4 degrader-3
GTR19277025-01PROTAC HDAC8 Degrader-3
GTR19262351-01PROTAC STAT3 degrader-3
GTR19258238-01PROTAC STING degrader-3
GTR19226855-01PROTAC BRD4 Degrader-3
GTR19204233-01PROTAC BET degrader-3

Alternative Products

CatalogName
T212556-01PROTAC sEH-degrader-3
HY-159494PROTAC sEH-degrader-1
HY-179166PROTAC sEH-degrader-4
HY-174443PROTAC sEH degrader-2
HY-175459PROTAC FAK degrader 3
HY-168551-01PROTAC ALK degrader-3
HY-135558PROTAC BRD4 Degrader-3
HY-161930PROTAC GPX4 degrader-3
HY-128527PROTAC ER Degrader-3
T18610-01PROTAC FKBP Degrader-3

Popular Products