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BAY-85-8501

CAT: 0804-HY-19908-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19908-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM.
CAS Number
1161921-82-9
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/BAY-85-8501.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
N#CC1=C(C)N(C2=CC=CC(C(F)(F)F)=C2)C(N(C)[C@@H]1C3=CC=C(C#N)C=C3S(=O)(C)=O)=O
Molecular Formula
C22H17F3N4O3S
Molecular Weight
474.46
References & Citations
[1]Von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10 (7) :1163-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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