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NLRP3-IN-75

CAT: 0013-GTR19258114-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258114-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-75 is an orally effective inhibitor of NLRP3, capable of suppressing IL-1β secretion with an IC50 of 23 nM. It selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting the assembly of NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 demonstrates excellent anti-inflammatory effects in models of acute peritonitis, diabetic nephropathy, and inflammatory bowel disease (IBD) .
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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