Products for Research Use Only
RegisterLogin

NLRP3-IN-86

CAT: 0013-GTR19274950-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19274950-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NLRP3-IN-86 (Compound 8a), a derivative of Songorine, is a potent and selective inhibitor of the NLRP3 inflammasome. It effectively reduces lactate dehydrogenase (LDH) release induced by LPS and Nigericin, with an IC50 of 2.69 μM in THP-1 cells and 1.75 μM in J774A.1 cells. Additionally, NLRP3-IN-86 inhibits the cleavage of gasdermin D (GSDMD) and the secretion of IL-1β, effectively suppressing pyroptosis. This compound is applicable for inflammation-related research.
CAS Number
2361570-54-7
Smiles
O[C@@H]1[C@]23[C@]4 ([C@@]5 ([C@@]6 (C2 (N (CC) C[C@@] (C) ([C@]3 (C6) [H]) CC1) [H]) [H]) C[C@@] (C (=O) C4) (C (=C) C5=O) [H]) [H]
Molecular Formula
C22H29NO3
Molecular Weight
355.48
Storage Conditions
-20°C
Notes
For research use only.

Related Products

CatalogName
GTR18900569-01NLRP3 peptide
GTR19243684-01NLRP3-IN-13
GTR19243206-01NLRP3-IN-71
GTR19238896-01NLRP3-IN-53
GTR19238804-01NLRP3-IN-49
GTR19237514-01NLRP3-IN-44
GTR19171614-01NLRP3-IN-9
GTR19273326-01NLRP3-IN-84
GTR19263241-01NLRP3-IN-81
GTR19262477-01NLRP3-IN-40

Alternative Products

CatalogName
ARC0894SU.86.86
QY-E06005Human NLRP3 Inflammasome (NLRP3)
MBS8534011-01NLRP3
CL-0820SU.86.86 Cell Line
BA6124-10NLRP3-IN-17

Popular Products