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NLRP3-IN-81

CAT: 0013-GTR19263241-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263241-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.
CAS Number
2922814-85-3
Field of Research
Cell Biology, Immunology & Inflammation, Protein Biochemistry
Smiles
O=S (=O) (C1=NN=C (C=C1) C=2C=CC (=CC2O) C (F) (F) F) C3CCCC3
Molecular Formula
C16H15F3N2O3S
Molecular Weight
372.36
Storage Conditions
-20°C
Notes
For research use only.

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