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NLRP3-IN-84

CAT: 0013-GTR19273326-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273326-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-84 (Compound 32) is an inhibitor of the NLRP3 inflammasome. It interferes with the oligomerization of NLRP3 by inhibiting the activity of NLRP3ATPase (IC50= 158.4 nM) . NLRP3-IN-84 also inhibits Caspase-1 (IC50= 27.7 nM), the release of IL-1β in PBMC (IC50= 19.5 nM) and mPBMC (IC50= 24.2 nM), and ASC speck formation (IC50= 131 nM) . It shows no inhibitory activity against the NLRC4 and AIM2 inflammasomes. NLRP3-IN-84 exhibits significant in vivo anti-inflammatory effects in a mouse acute peritonitis model, making it useful for studying NLRP3-related inflammatory diseases.
Storage Conditions
-20°C
Notes
For research use only.

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