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PROTAC CDK9 degrader-11

CAT: 0013-GTR19249129-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249129-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC CDK9 degrader-11 (C3) is an orally bioavailable, potent degrader (DC50 = 1.09 nM) demonstrating nanomolar cytotoxicity in SCLC models. It induces G0/G1 arrest, inhibits invasion in vitro, and shows in vivo antitumor efficacy in an NCI-H446 xenograft model, supporting its use in oncology and targeted protein degradation research.
CAS Number
3039540-19-4
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O=C (NC1=CNN=C1C (=O) NC2CCN (C (=O) CN3CCC (CN4CCN (C=5C=CC=C (C5) NC6C (=O) NC (=O) CC6) CC4) CC3) CC2) C=7C (Cl) =CC=CC7Cl
Molecular Formula
C39H48Cl2N10O5
Molecular Weight
807.768
Storage Conditions
-20°C
Notes
For research use only.

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