PROTAC ERα Degrader-2

• CAS Number:

  1351169-29-3

• UNSPSC Description:

  PROTAC ERα Degrader-2 comprises a IAP ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

• Target Antigen:

  Estrogen Receptor/ERR; PROTACs; SNIPERs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-er-alpha-degrader-2.html

• Purity:

  98.92

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[C@](CC/C2=N\OCC(NCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)=O)=O)([H])[C@@]4([H])[C@](C5=CC=C(O)C=C5CC4)([H])CC1

• Molecular Weight:

  763.96

• References & Citations:

  [1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported