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PROTAC AR Degrader-12

CAT: 0013-GTR19275852-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275852-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTACAR Degrader-12 is an effective PROTAC that targets the androgen receptor (AR) co-activator binding site (AR-CBS) . It induces AR degradation via the ubiquitin-proteasome system (UPS) pathway, inhibiting tumor cell growth by affecting DNA replication and cell division. Besides effectively degrading AR, it strongly inhibits the proliferation of MCF-7 cells and various mutant or drug-resistant breast cancer cells. PROTACAR Degrader-12 blocks the estrogen receptor α (ERα) signaling pathway through dual mechanisms of ERα protein downregulation and transcriptional activity inhibition, significantly suppressing mRNA expression of FOXA1, GREB1, SRC, and PELP1. It is applicable in breast cancer research.
Storage Conditions
-20°C
Notes
For research use only.

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