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MGD-28

CAT: 0013-GTR19240604-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240604-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MGD-28 is a potent, orally bioavailable CRBN-based degrader of IKZF proteins (Ikaros, Helios, Aiolos) and CK1α. It demonstrates nanomolar antiproliferative activity in hematologic cancer cell lines in vitro and antitumor efficacy in vivo, supporting its research use in multiple myeloma and related hematological malignancies.
CAS Number
2991818-13-2
Product Name Alternative
MGD28
Field of Research
Immunology & Inflammation, Metabolism Research, Stem Cell & Developmental Biology
Purity
99.39% (May vary between batches)
Smiles
N#CC1=CC=C (C=C1F) N2CCN (CC3=CC=C (C=C3) CNC4=CC=CC=5C (=O) N (N (C) CC45) C6C (=O) NC (=O) CC6) CC2
Molecular Formula
C33H34FN7O3
Molecular Weight
595.67
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-[4-[[4-[[[2-(2,6-dioxopiperidin-3-yl)-3-methyl-1-oxo-4H-phthalazin-5-yl]amino]methyl]phenyl]methyl]piperazin-1-yl]-2-fluorobenzonitrile
CAS Number2991818-13-2
PubChem CID172871692
IUPAC Name4-[4-[[4-[[[2-(2,6-dioxopiperidin-3-yl)-3-methyl-1-oxo-4H-phthalazin-5-yl]amino]methyl]phenyl]methyl]piperazin-1-yl]-2-fluorobenzonitrile
Molecular FormulaC33H34FN7O3
Molecular Weight595.7
XLogP3.1
Topological Polar Surface Area112
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count44
Formal Charge0
Complexity1100
SMILES
CN1CC2=C(C=CC=C2NCC3=CC=C(C=C3)CN4CCN(CC4)C5=CC(=C(C=C5)C#N)F)C(=O)N1C6CCC(=O)NC6=O
InChI
InChI=1S/C33H34FN7O3/c1-38-21-27-26(33(44)41(38)30-11-12-31(42)37-32(30)43)3-2-4-29(27)36-19-22-5-7-23(8-6-22)20-39-13-15-40(16-14-39)25-10-9-24(18-35)28(34)17-25/h2-10,17,30,36H,11-16,19-21H2,1H3,(H,37,42,43)
InChIKey
JICHBFQDRLGJTM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[4-[[4-[[[2-(2,6-dioxopiperidin-3-yl)-3-methyl-1-oxo-4H-phthalazin-5-yl]amino]methyl]phenyl]methyl]piperazin-1-yl]-2-fluorobenzonitrile
CAS: 2991818-13-2
CID: 172871692
Formula: C33H34FN7O3
MW: 595.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight595.7
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass595.27071613
Monoisotopic Mass595.27071613
Topological Polar Surface Area112 Ų
Heavy Atom Count44
Formal Charge0
Complexity1100
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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