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PLX-3618

CAT: 0013-GTR19236746-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236746-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLX-3618 is a potent monovalent degrader of BRD4 (DC50 = 12.2 nM) that operates via DCAF11-mediated ubiquitination and proteasomal degradation. It demonstrates anti-proliferative and pro-apoptotic activity in AML and other cancer cell lines, with confirmed efficacy in mouse models of acute myeloid leukemia.
CAS Number
2851986-76-8
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
99.71% (May vary between batches)
Smiles
CC=1C2=C (N3C ([C@H] (CC (N) =O) N=C2C4=CC=C (C=C4) C5=CC (NC (=O) C6=C7N (N=C6) C=CC=N7) =CC=C5) =NN=C3C) SC1C
Molecular Formula
C32H27N9O2S
Molecular Weight
601.68
Storage Conditions
-20°C
Notes
For research use only.

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