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PLX-4720

CAT: 0013-GTR19160794-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160794-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent and selective inhibitor of B-Raf V600E with IC50 of 13 nM; dispalys 10-fold selectivity over wild-type B-Raf, and remarkably selective against a diverse panel of 70 other kinases; inhibits ERK phosphorylation in COLO25 cells with IC50 of 14 nM; induces cell cycle arrest and apoptosis exclusively in B-Raf (V600E) -positive cells. In B-Raf (V600E) -dependent tumor xenograft models; orally active.Skin Cancer Preclinical.
CAS Number
918505-84-7
Product Name Alternative
PLX4720 | PLX 4720
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CCCS (=O) (NC1=CC=C (F) C (C (C2=CNC3=NC=C (Cl) C=C32) =O) =C1F) =O
Molecular Formula
C17H14ClF2N3O3S
Molecular Weight
413.8262
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Propanesulfonamide, N-[3-[ (5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl) carbonyl]-2,4-difluorophenyl]-

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