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PLX-4545

CAT: 0013-GTR19236196-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19236196-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLX-4545 is an orally active, cereblon-dependent molecular glue that degrades IKZF2 (Helios) . This degradation reprograms immunosuppressive regulatory T cells into pro-inflammatory effector cells, thereby enhancing anti-tumor immunity. Its application in cancer immunotherapy research includes in vitro mechanistic studies and in vivo tumor model evaluations.
CAS Number
2892065-45-9
Field of Research
Pharmacology & Drug Discovery
Smiles
O ([C@@H]1[C@H] (CCCC1) N2CC (C2) C3=CC=CC=C3) C=4C=C5C (=CC4) C (=O) N (C5) [C@@H]6C (=O) NC (=O) CC6
Molecular Formula
C28H31N3O4
Molecular Weight
473.56
Storage Conditions
-20°C
Notes
For research use only.

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