PLX-4545

• Description :

  PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios) . PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses[1].

• CAS Number :

  [2892065-45-9]

• UNSPSC :

  12352005

• Target :

  IKZF Family; Molecular Glues

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/plx-4545.html

• Purity :

  96.76

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1CC[C@@H](C(N1)=O)N2CC3=C(C2=O)C=CC(O[C@H]4CCCC[C@@H]4N5CC(C5)C6=CC=CC=C6)=C3

• Molecular Formula :

  C28H31N3O4

• Molecular Weight :

  473.56

• References & Citations :

  [1]Huang Y, et al. PLX-4545, a selective IKZF2 degrader, reprograms suppressive Tregs leading to tumor growth inhibition and combination benefit with immune checkpoint therapy[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 6380-6380.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IKZF2