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PLX-3618

CAT: 0931-T88470-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88470-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2851986-76-8
Target
Apoptosis, Epigenetic Reader Domain, Molecular Glues
Related Pathways
Apoptosis, PROTAC, Chromatin/Epigenetic
Bioactivity
PLX-3618 is a monovalent direct degrader capable of degrading BRD4 with a DC50 of 12.2 nM. It promotes the polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting the E3 ubiquitin ligase substrate receptor DCAF11. Furthermore, PLX-3618 inhibits the proliferation of various cancer cells and induces apoptosis in AML cells. It also demonstrates anti-tumor activity against AML in mouse models.
Smiles
CC=1C2=C(N3C([C@H](CC(N)=O)N=C2C4=CC=C(C=C4)C5=CC(NC(=O)C6=C7N(N=C6)C=CC=N7)=CC=C5)=NN=C3C)SC1C
Molecular Formula
C32H27N9O2S
Molecular Weight
601.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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