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PLX-8394

CAT: 0013-GTR19163328-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163328-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent and selective Raf inhibitor with biochemical IC50 of 3.8/14/23 nM for BRaf V600E/BRAF/CRAF, respectively; shows pERK inhibition in A375 and COLO829 cells with IC50 of 3.5 nM and 2.1 nM, respectively; and do not elicit paradoxical ERK1/2 activation in mutant RAS expressing cells; exhibits effectivity in both BRAFV600E and certain non-V600 LA models, in vitro and in vivo.Skin Cancer Phase 2 Clinical.
CAS Number
1393466-87-9
Product Name Alternative
PLX 8394
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 39 mg/mL
Smiles
O=S (N1C[C@H] (F) CC1) (NC2=CC=C (F) C (C (C3=CNC4=NC=C (C5=CN=C (C6CC6) N=C5) C=C43) =O) =C2F) =O
Molecular Formula
C25H21F3N6O3S
Molecular Weight
542.5328
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Pyrrolidinesulfonamide, N-[3-[[5- (2-cyclopropyl-5-pyrimidinyl) -1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-3-fluoro-, (3R) -

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