Products for Research Use Only
RegisterLogin

PHD-IN-2

CAT: 0013-GTR19230254-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19230254-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PHD-IN-2 (Compound 91) is a potent PHD inhibitor (IC50 < 5 nM) that induces erythropoietin production in vitro (EC50 < 2.5 μM in HEP3B cells) . Its research applications span studies of anemia, ischemia, and metabolic disorders, supported by investigations in cellular and animal models of hypoxia-related pathophysiology.
CAS Number
2924182-42-1
Field of Research
Epigenetics & Chromatin, Metabolism Research
Smiles
C (OC (C) (C) C) (=O) N1CC2 (CN (C2) C3=NC4=C (C=C3) C (O) =C (C (NCC=5C=CC (C#N) =NC5) =O) N=C4) C1
Molecular Formula
C26H27N7O4
Molecular Weight
501.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Phd-IN-2
CAS Number2924182-42-1
PubChem CID168476176
IUPAC Nametert-butyl 6-[6-[(6-cyano-3-pyridinyl)methylcarbamoyl]-5-hydroxy-1,7-naphthyridin-2-yl]-2,6-diazaspiro[3.3]heptane-2-carboxylate
Molecular FormulaC26H27N7O4
Molecular Weight501.5
XLogP2.4
Topological Polar Surface Area145
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count37
Formal Charge0
Complexity916
SMILES
CC(C)(C)OC(=O)N1CC2(C1)CN(C2)C3=NC4=CN=C(C(=C4C=C3)O)C(=O)NCC5=CN=C(C=C5)C#N
InChI
InChI=1S/C26H27N7O4/c1-25(2,3)37-24(36)33-14-26(15-33)12-32(13-26)20-7-6-18-19(31-20)11-29-21(22(18)34)23(35)30-10-16-4-5-17(8-27)28-9-16/h4-7,9,11,34H,10,12-15H2,1-3H3,(H,30,35)
InChIKey
GWUYHNJGQULKDQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Phd-IN-2
CAS: 2924182-42-1
CID: 168476176
Formula: C26H27N7O4
MW: 501.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight501.5
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass501.21245237
Monoisotopic Mass501.21245237
Topological Polar Surface Area145 Ų
Heavy Atom Count37
Formal Charge0
Complexity916
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19234792-01PHD-IN-3
GTR19274567-01PHD-IN-5
GTR17987095Phd Antibody
GTR19230255-01PHD-IN-1
GTR19164678-01PHD-1-IN-1
GTR19243659-01HIF-PHD-IN-3
GTR19220626-01HIF-PHD-IN-3
GTR19259024-01HIF-PHD-IN-4
GTR19213221UHRF1 PHD inhibitor MLD4
GTR19013004-01PHD finger protein 1

Alternative Products

CatalogName
T79798-01PHD-IN-2
HY-139993HIF-PHD-IN-2
CST 3293SPHD-2/Egln1 Antibody
F0587-01PHD-2/Egln1 Rabbit mAb
C18951-50uLPHD-2/Egln1 Antibody [C1P15]
HY-163148PHD-IN-3
T79797-01PHD-IN-1
MBS1049426-01Recombinant Enterobacteria phage P1 Antitoxin phd (phd)
abx236384PHD Finger Protein 2 (PHF2) Antibody
BA7815-1HIF-PHD-IN-1

Popular Products