Products for Research Use Only
RegisterLogin

PROTAC ATR degrader-2

CAT: 0013-GTR19234729-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19234729-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PROTAC ATR degrader-2 (Compound 8i) is a potent and selective ATR degrader with DC50 values of 22.9 nM and 34.5 nM in MV-4-11 and MOLM-13 AML cell lines, respectively. It induces apoptosis, inhibits proliferation, and demonstrates favorable pharmacokinetics and antitumor efficacy in an AML mouse model, supporting its use in oncology and targeted protein degradation research.
CAS Number
3010273-12-5
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
N (C (CCCCN1CCN (C (=O) C2=CC=C (C=C2) C3=NC (C (NC4=CC=CC=C4) =O) =C (N) N=C3) CC1) =O) C5=C6C (C (=O) N (C6) C7C (=O) NC (=O) CC7) =CC=C5
Molecular Formula
C40H41N9O6
Molecular Weight
743.81
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PROTAC ATR degrader-2
CAS Number3010273-12-5
PubChem CID171714318
IUPAC Name3-amino-6-[4-[4-[5-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]amino]-5-oxopentyl]piperazine-1-carbonyl]phenyl]-N-phenylpyrazine-2-carboxamide
Molecular FormulaC40H41N9O6
Molecular Weight743.8
XLogP1.9
Topological Polar Surface Area200
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Heavy Atom Count55
Formal Charge0
Complexity1410
SMILES
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3NC(=O)CCCCN4CCN(CC4)C(=O)C5=CC=C(C=C5)C6=CN=C(C(=N6)C(=O)NC7=CC=CC=C7)N
InChI
InChI=1S/C40H41N9O6/c41-36-35(38(53)43-27-7-2-1-3-8-27)45-31(23-42-36)25-12-14-26(15-13-25)39(54)48-21-19-47(20-22-48)18-5-4-11-33(50)44-30-10-6-9-28-29(30)24-49(40(28)55)32-16-17-34(51)46-37(32)52/h1-3,6-10,12-15,23,32H,4-5,11,16-22,24H2,(H2,41,42)(H,43,53)(H,44,50)(H,46,51,52)
InChIKey
KHFPFRKCBBCWLB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PROTAC ATR degrader-2
CAS: 3010273-12-5
CID: 171714318
Formula: C40H41N9O6
MW: 743.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight743.8
XLogP31.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Exact Mass743.31798006
Monoisotopic Mass743.31798006
Topological Polar Surface Area200 Ų
Heavy Atom Count55
Formal Charge0
Complexity1410
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19234730-01PROTAC ATR degrader-1
GTR19225744-01PROTAC CDK9 degrader-2
GTR19225043-01PROTAC ERα Degrader-2
GTR19249811-01PROTAC HDAC6 degrader 2
GTR19231490-01PROTAC TG2 degrader-2
GTR19218642-01PROTAC SMARCA2 degrader-2
GTR19277043-01PROTAC HMGCR Degrader-2
GTR19277031-01PROTAC TEAD degrader-2
GTR19275904-01PROTAC USP7 Degrader-2
GTR19263524-01PROTAC HDAC degrader-2

Alternative Products

CatalogName
HY-178803PROTAC BCL6 Degrader-2
HY-169072PROTAC MLKL Degrader-2
HY-163938APROTAC erf3a Degrader-2
HY-158036PROTAC STING Degrader-2
HY-128841-01PROTAC MDM2 Degrader-2
T211019-01PROTAC HDAC degrader-2
T210290-01PROTAC ALK degrader-2
T89589-01PROTAC PARP1 degrader-2
HY-111866-01PROTAC RIPK degrader-2
HY-145395PROTAC BRD9 Degrader-2

Popular Products