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PROTAC PARP1 degrader

CAT: 0013-GTR19226848-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19226848-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This small molecule PROTAC induces targeted degradation of PARP1. It demonstrates in vitro activity with an IC50 of 6.12 μM in MDA-MB-231 breast cancer cells after 24-hour treatment. Such degraders are valuable research tools for studying PARP1 biology and exploring novel therapeutic strategies in oncology.
CAS Number
2369022-68-2
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.42% (May vary between batches)
Smiles
C (=O) (N1[C@H] ([C@H] (N=C1C2=C (OC (C) C) C=C (OC) C=C2) C3=CC=C (Cl) C=C3) C4=CC=C (Cl) C=C4) N5CC (=O) N (CC (NCCOCCOCCOCCOCCN6C=C (N=N6) C7=CC=C (C=C7) N8N=C9C (=C8) C=CC=C9C (N) =O) =O) CC5
Molecular Formula
C58H63Cl2N11O10
Molecular Weight
1145.1
Storage Conditions
-20°C
Notes
For research use only.

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