Products for Research Use Only
RegisterLogin

KTX-497

CAT: 0013-GTR19221044-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19221044-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
KTX-497 is a potent and selective IRAK4 degrader with a DC50 of 3 nM. This small molecule is a valuable research tool for oncology, enabling the study of IRAK4's role in cancer cell signaling and tumor progression in both in vitro and in vivo models.
CAS Number
2432993-46-7
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction
Smiles
CC (C) (O) c1cc2nn (cc2cc1NC (=O) c1cccc (n1) C (F) (F) F) [C@H]1CC[C@H] (CN2CCC3 (CC (C3) Nc3cccc4C (=O) N (C5CCC (=O) NC5=O) C (=O) c34) CC2) CC1
Molecular Formula
C45H49F3N8O6
Molecular Weight
854.92
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[2-[4-[[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-7-azaspiro[3.5]nonan-7-yl]methyl]cyclohexyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
CAS Number2432993-46-7
PubChem CID155449220
IUPAC NameN-[2-[4-[[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-7-azaspiro[3.5]nonan-7-yl]methyl]cyclohexyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
Molecular FormulaC45H49F3N8O6
Molecular Weight854.9
XLogP5.4
Topological Polar Surface Area179
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count13
Rotatable Bond Count9
Heavy Atom Count62
Formal Charge0
Complexity1730
SMILES
CC(C)(C1=CC2=NN(C=C2C=C1NC(=O)C3=NC(=CC=C3)C(F)(F)F)C4CCC(CC4)CN5CCC6(CC5)CC(C6)NC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O)O
InChI
InChI=1S/C45H49F3N8O6/c1-43(2,62)30-20-33-26(19-34(30)51-39(58)32-7-4-8-36(50-32)45(46,47)48)24-55(53-33)28-11-9-25(10-12-28)23-54-17-15-44(16-18-54)21-27(22-44)49-31-6-3-5-29-38(31)42(61)56(41(29)60)35-13-14-37(57)52-40(35)59/h3-8,19-20,24-25,27-28,35,49,62H,9-18,21-23H2,1-2H3,(H,51,58)(H,52,57,59)
InChIKey
DLTLPZXACUDKBE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[2-[4-[[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-7-azaspiro[3.5]nonan-7-yl]methyl]cyclohexyl]-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
CAS: 2432993-46-7
CID: 155449220
Formula: C45H49F3N8O6
MW: 854.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight854.9
XLogP35.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count13
Rotatable Bond Count9
Exact Mass854.37271580
Monoisotopic Mass854.37271580
Topological Polar Surface Area179 Ų
Heavy Atom Count62
Formal Charge0
Complexity1730
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19221047-01KTX-582
GTR19258677-01KTX-005
GTR19061705-01KTX-Sp2
GTR19221043-01KTX-612
GTR19221040-01KTX-951
GTR19221045-01KTX-955
GTR19061714-01Aam-KTX
GTR19212054-01NG-497
GTR19198498-01AA 497 HCl
GTR19276022-01CRBN ligand-497

Alternative Products

CatalogName
T74666-01KTX-497
HY-148290-01KTX-951
HY-P5870KTX-Sp2
T80483-01Aam-KTX
HY-173031KTX-005
HY-148275KTX-955
T74664-01KTX-582
HY-148277KTX-612
BA7203-10NG-497
HY-121043AAA 497

Popular Products