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MK-287

CAT: 0013-GTR19193511-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19193511-01Size:25 mg
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Description
MK-287 (L-680573) is a potent platelet-activating factor (PAF) antagonist that inhibits [3H]C18-PAF binding to human platelets, polymorphonuclear leukocytes, and pulmonary membranes. It has been investigated in preclinical research for asthma and related inflammatory conditions, with studies conducted both in vitro and in vivo.
CAS Number
135947-75-0
Smiles
O (CCC) C1=C (S (CCO) (=O) =O) C=C (C=C1OC) [C@H]2O[C@@H] (CC2) C3=CC (OC) =C (OC) C (OC) =C3
Molecular Formula
C25H34O9S
Molecular Weight
510.6
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

MK 287

RN given refers to the trans-(-)-isomer L-680573; L-680574 is an optical enantiomer; L-668750 is the racemic mixture; structure given in first source

CAS Number135947-75-0
PubChem CID131925
IUPAC Name2-[3-methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]sulfonylethanol
Molecular FormulaC25H34O9S
Molecular Weight510.6
XLogP2.9
Topological Polar Surface Area118
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count12
Heavy Atom Count35
Formal Charge0
Complexity713
SMILES
CCCOC1=C(C=C(C=C1S(=O)(=O)CCO)[C@@H]2CC[C@H](O2)C3=CC(=C(C(=C3)OC)OC)OC)OC
InChI
InChI=1S/C25H34O9S/c1-6-10-33-25-22(31-4)14-17(15-23(25)35(27,28)11-9-26)19-8-7-18(34-19)16-12-20(29-2)24(32-5)21(13-16)30-3/h12-15,18-19,26H,6-11H2,1-5H3/t18-,19-/m0/s1
InChIKey
WXIDMVGKJBAEFP-OALUTQOASA-N
Chemical Structure
2D Structure
2D structure of MK 287
CAS: 135947-75-0
CID: 131925
Formula: C25H34O9S
MW: 510.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight510.6
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count12
Exact Mass510.19235383
Monoisotopic Mass510.19235383
Topological Polar Surface Area118 Ų
Heavy Atom Count35
Formal Charge0
Complexity713
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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