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TH-287

CAT: 0013-GTR19162985-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162985-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM; shows no relevant inhibition for MTH2, NUDT5, NUDT12, NUDT14, NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
CAS Number
1609960-30-6
Product Name Alternative
TH287
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 2.6 mg/mL
Smiles
NC1=NC (C2=CC=CC (Cl) =C2Cl) =CC (NC) =N1
Molecular Formula
C11H10Cl2N4
Molecular Weight
269.1299
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Pyrimidinediamine, 6- (2,3-dichlorophenyl) -N4-methyl-

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