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SHP2-IN-8

CAT: 0013-GTR19186629-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186629-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHP2-IN-8 is a potent, selective, and reversible allosteric inhibitor of SHP2 with an IC50 of 23 nM. It induces target thermal stabilization (ΔTm = 7.01°C) and demonstrates cellular activity by inhibiting AKT phosphorylation and promoting apoptosis in HeLa cells, useful for cancer signaling research.
CAS Number
1801692-60-3
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Smiles
NC=1N=C (N2CCC (CN) (C) CC2) C=NC1SC3=C (Cl) C (Cl) =CC=C3
Molecular Formula
C17H21Cl2N5S
Molecular Weight
398.35
Storage Conditions
-20°C
Notes
For research use only.

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