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Tyrphostin AG 112

CAT: 0013-GTR19184077-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19184077-01Size:5 mg
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Description
Tyrphostin AG 112 is a selective EGFR tyrosine kinase inhibitor that blocks receptor autophosphorylation. This compound is a valuable research tool for studying EGFR signaling pathways in cancer biology, applicable in both in vitro cellular assays and in vivo model systems.
CAS Number
144978-82-5
Product Name Alternative
Tyrphostin AG 112, Tyrphostin AG112, Tyrphostin AG-112, inhibit, Inhibitor, HER1, Epidermal growth factor receptor, ErbB-1, EGFR
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.01% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.47 mM) ; DMSO:50 mg/mL (211.66 mM)
Smiles
C (=C (C (=C (C#N) C#N) N) C#N) C1=CC=C (O) C=C1
Molecular Formula
C13H8N4O
Molecular Weight
236.23
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AG 112

2-amino-4-(4-hydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile is a member of phenols.

CAS Number144978-82-5
PubChem CID5328804
IUPAC Name(3Z)-2-amino-4-(4-hydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile
Molecular FormulaC13H8N4O
Molecular Weight236.23
XLogP0.9
Topological Polar Surface Area118
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity505
SMILES
C1=CC(=CC=C1/C=C(\C#N)/C(=C(C#N)C#N)N)O
InChI
InChI=1S/C13H8N4O/c14-6-10(13(17)11(7-15)8-16)5-9-1-3-12(18)4-2-9/h1-5,18H,17H2/b10-5+
InChIKey
DXVJRTIPBNBLLB-BJMVGYQFSA-N
Chemical Structure
2D Structure
2D structure of AG 112
CAS: 144978-82-5
CID: 5328804
Formula: C13H8N4O
MW: 236.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight236.23
XLogP30.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass236.06981089
Monoisotopic Mass236.06981089
Topological Polar Surface Area118 Ų
Heavy Atom Count18
Formal Charge0
Complexity505
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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