Products for Research Use Only
RegisterLogin

Tyrphostin 8

CAT: 0804-HY-W174279-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W174279-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM) [1][2][3].
CAS Number
3785-90-8
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
EGFR; Phosphatase; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tyrphostin-8.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C1=C(C=CC(=C1)O)C=C(C#N)C#N
Molecular Formula
C10H6N2O
Molecular Weight
170.17
Precautions
H301, H315, H319, H335
References & Citations
[1]Soltoff SP. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279 (12) :10910-8.|[2]Xia CQ, et, al. Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharm Res. 2001 Feb;18 (2) :191-5.|[3]Martin BL. Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors. Biochem Pharmacol. 1998 Aug 15;56 (4) :483-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

Related Products

CatalogName
HY-101959ATyrphostin 47
HY-101960ATyrphostin A51
HY-118532-01Tyrphostin AG30
HY-101959-01Tyrphostin AG213
HY-15511-01Tyrphostin A9
HY-13894-01Tyrphostin AG1296
HY-119757-01Tyrphostin AG1433
HY-101958-01Tyrphostin 25
HY-101007A-01(+) -Tyrphostin B44
HY-169755Tyrphostin 63

Alternative Products

CatalogName
B1494-50Tyrphostin 9
A4681-50Tyrphostin A1
T7101-01Tyrphostin AG30
T2063-01Tyrphostin 23
T21622-01Tyrphostin A25
468388-01Tyrphostin A9
468386-01Tyrphostin 51
468385-01Tyrphostin 47
T24910-01Tyrphostin A46
T13238-01Tyrphostin AG1433

Popular Products