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Tyrphostin A51

CAT: 0804-HY-101960ASize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101960ASize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2].
CAS Number
126433-07-6
Product Name Alternative
AG-183
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tyrphostin-a51.html
Purity
99.0
Solubility
DMSO : 50 mg/mL (ultrasonic; warming)
Smiles
N#C/C(C#N)=C(N)/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1
Molecular Formula
C13H8N4O3
Molecular Weight
268.23
References & Citations
[1]Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230.|[2]Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63 (3) :243-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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