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Tyrphostin AG 538

CAT: 0013-GTR19211864-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19211864-01Size:1 mg
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Description
Tyrphostin AG 538 is a cell-permeable, reversible, and competitive chalcone inhibitor of the IGF-1 receptor kinase with an IC50 of 400 nM. It is used in research to study IGF-1R signaling in cancer biology and has been applied in both in vitro and in vivo experimental models.
CAS Number
133550-18-2
Product Name Alternative
AG 538, AG538, AG-538, IGF1R, IGF-1R, Tyrphostin AG538, Tyrphostin AG-538, Tyrphostin AG 538
Field of Research
Signal Transduction
Purity
98.75% (May vary between batches)
Solubility
DMSO:4.5 mg/mL (15.14 mM)
Smiles
C (/C (=C/C1=CC (O) =C (O) C=C1) /C#N) (=O) C2=CC (O) =C (O) C=C2
Molecular Formula
C16H11NO5
Molecular Weight
297.26
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AG-538

3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile is a member of chalcones.

CAS Number133550-18-2
PubChem CID5328760
IUPAC Name(E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
Molecular FormulaC16H11NO5
Molecular Weight297.26
XLogP2.2
Topological Polar Surface Area122
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity494
SMILES
C1=CC(=C(C=C1/C=C(\C#N)/C(=O)C2=CC(=C(C=C2)O)O)O)O
InChI
InChI=1S/C16H11NO5/c17-8-11(5-9-1-3-12(18)14(20)6-9)16(22)10-2-4-13(19)15(21)7-10/h1-7,18-21H/b11-5+
InChIKey
CANOJKGQDCJDOX-VZUCSPMQSA-N
Chemical Structure
2D Structure
2D structure of AG-538
CAS: 133550-18-2
CID: 5328760
Formula: C16H11NO5
MW: 297.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight297.26
XLogP32.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass297.06372245
Monoisotopic Mass297.06372245
Topological Polar Surface Area122 Ų
Heavy Atom Count22
Formal Charge0
Complexity494
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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