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Tyrphostin AG 528

CAT: 0013-GTR19170735-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170735-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyrphostin AG 528 (B66) is a dual inhibitor of EGFR and ErbB2 tyrosine kinases, exhibiting IC50 values of 4.9 μM and 2.1 μM, respectively. It is a research tool used in vitro to study oncogenic signaling pathways and explore potential therapeutic strategies in cancer research, particularly involving the ErbB receptor family.
CAS Number
133550-49-9
Product Name Alternative
Tyrphostin AG528, Tyrphostin AG-528, Tyrphostin B 66, Tyrphostin B66, Tyrphostin B-66, Tyrphostin AG 528, AG 528, AG528, AG-528, ErbB2, EGFR
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.64% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.53 mM) ; DMSO:55 mg/mL (179.55 mM)
Smiles
Oc1ccc (\C=C (\C#N) C (=O) N2CCc3ccccc23) cc1O
Molecular Formula
C18H14N2O3
Molecular Weight
306.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tyrphostin AG528
CAS Number133550-49-9
PubChem CID1838043
IUPAC Name(E)-2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
Molecular FormulaC18H14N2O3
Molecular Weight306.3
XLogP2.6
Topological Polar Surface Area84.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity536
SMILES
C1CN(C2=CC=CC=C21)C(=O)/C(=C/C3=CC(=C(C=C3)O)O)/C#N
InChI
InChI=1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+
InChIKey
MYKCTDWWIWGLHW-NTEUORMPSA-N
Chemical Structure
2D Structure
2D structure of Tyrphostin AG528
CAS: 133550-49-9
CID: 1838043
Formula: C18H14N2O3
MW: 306.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.3
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass306.10044231
Monoisotopic Mass306.10044231
Topological Polar Surface Area84.6 Ų
Heavy Atom Count23
Formal Charge0
Complexity536
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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