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CHIR-99021

CAT: 0013-GTR19173962-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173962-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIR-99021 is a potent, selective, and orally active GSK-3α/β inhibitor that activates Wnt/β-catenin signaling. It is widely used in stem cell research to promote self-renewal of embryonic stem cells by inducing autophagy, and has applications in studies of development, metabolism, and regeneration in vitro and in vivo.
CAS Number
252917-06-9
Product Name Alternative
Beta catenin, beta-catenin, betacatenin, CHIR 99021, CHIR99021, CHIR-99021, CT99021, CT-99021, CT 99021, Autophagy, bcatenin, Laduviglusib, Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK-3β, GSK-3α, GSK3, GSK-3, inhibit, βcatenin, β-catenin, Wnt, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
≥95% (May vary between batches)
Solubility
DMSO: 105 mg/mL (225.64 mM), Sonication is recommended.
Smiles
Cc1c[nH]c (n1) -c1cnc (NCCNc2ccc (cn2) C#N) nc1-c1ccc (Cl) cc1Cl
Molecular Formula
C22H18Cl2N8
Molecular Weight
465.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Laduviglusib

CHIR 99021 is a member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a cyanopyridine, a diamine, a dichlorobenzene, a member of imidazoles, an aminopyridine, an aminopyrimidine and a secondary amino compound.

CAS Number252917-06-9
PubChem CID9956119
IUPAC Name6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
Molecular FormulaC22H18Cl2N8
Molecular Weight465.3
XLogP4.3
Topological Polar Surface Area115
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity645
SMILES
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
InChI
InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
InChIKey
AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Laduviglusib
CAS: 252917-06-9
CID: 9956119
Formula: C22H18Cl2N8
MW: 465.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight465.3
XLogP34.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass464.1031480
Monoisotopic Mass464.1031480
Topological Polar Surface Area115 Ų
Heavy Atom Count32
Formal Charge0
Complexity645
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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474084CHIR 99021
M13747-01CHIR-99021
T2310L-01CHIR-99021 HCl
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MBS3602717-01CHIR-99021 monohydrochloride
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