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CHIR-98014

CAT: 0013-GTR19173688-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173688-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIR-98014 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor. It enhances insulin-stimulated glucose uptake and metabolism in both cellular and animal models, making it a valuable research tool for studying diabetes, insulin resistance, and Wnt/β-catenin signaling pathways.
CAS Number
252935-94-7
Product Name Alternative
BFGFR, CT98014, CT 98014, c-Src, CT-98014, CHIR 98014, CHIR-98014, CHIR98014, p70 S6K, inhibit, Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK-3β, GSK-3α, GSK3, GSK-3, S6 Kinase, S6Kinase
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.09% (May vary between batches)
Solubility
DMSO:4.87 mg/mL (10.01 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
ClC1=C (C=2C (=CN=C (NCCNC=3N=C (N) C (N (=O) =O) =CC3) N2) N4C=CN=C4) C=CC (Cl) =C1
Molecular Formula
C20H17Cl2N9O2
Molecular Weight
486.31
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine

CHIR-98014 is a member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.65 and 0.58 nM, respectively). It has a role as a Wnt signalling activator, a tau aggregation inhibitor, a hypoglycemic agent, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a dichlorobenzene, a member of imidazoles, a C-nitro compound, an aminopyrimidine, a secondary amino compound and a diaminopyridine.

CAS Number252935-94-7
PubChem CID53396311
IUPAC Name6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine
Molecular FormulaC20H17Cl2N9O2
Molecular Weight486.3
XLogP4.2
Topological Polar Surface Area152
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count33
Formal Charge0
Complexity645
SMILES
C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N
InChI
InChI=1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)
InChIKey
MDZCSIDIPDZWKL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine
CAS: 252935-94-7
CID: 53396311
Formula: C20H17Cl2N9O2
MW: 486.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight486.3
XLogP34.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass485.0882262
Monoisotopic Mass485.0882262
Topological Polar Surface Area152 Ų
Heavy Atom Count33
Formal Charge0
Complexity645
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A8395-5CHIR-98014
6695/25CHIR 98014

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