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CHIR-98014

CAT: 0013-GTR19162491-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162491-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; shows less potent activities against 20 other protein kinases including Cdc2 and Erk2; causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively; reduces the viability of ES-CCE cells with IC50 of 1.1 uM, results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells combined with CHIR-99021; significantly reduces fasting hyperglycemia within and shows improved glucose disposal in diabetic and insulin-resistant db/db mice.
CAS Number
252935-94-7
Product Name Alternative
CHIR98014 | CHIR 98014
Purity
>98% (HPLC)
Solubility
DMSO: 11 mg/mL
Smiles
NC1=C (C=CC (NCCNC2=NC=C (N3C=CN=C3) C (=N2) C2=C (Cl) C=C (Cl) C=C2) =N1) [N+] ([O-]) =O
Molecular Formula
C20H17Cl2N9O2
Molecular Weight
486.3141
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,6-Pyridinediamine, N6-[2-[[4- (2,4-dichlorophenyl) -5- (1H-imidazol-1-yl) -2-pyrimidinyl]amino]ethyl]-3-nitro-

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Alternative Products

CatalogName
A8395-5CHIR-98014
6695/25CHIR 98014

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