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CHIR-090

CAT: 0013-GTR19160259-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160259-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIR-090 is a very potent and selective LpxC inhibitor. CHIR-090 has excellent antibiotic activity against Pseudomonas aeruginosa and Escherichia coli. CHIR-090 is also a two-step slow, tight-binding inhibitor of E. coli LpxC with Ki = 4.0 nM, Ki* = 0.5 nM, k5 = 1.9 min-1, and k6 = 0.18 min-1. CHIR-090 at low nanomolar levels inhibits LpxC orthologues from diverse Gram-negative pathogens, including P. aeruginosa, Neisseria meningitidis, and Helicobacter pylori. In contrast, CHIR-090 is a relatively weak competitive and conventional inhibitor (lacking slow, tight-binding kinetics) of LpxC from Rhizobium leguminosarum (Ki = 340 nM), a Gram-negative plant endosymbiont that is resistant to this compound. CHIR-090 is an excellent lead for the further development of new antibiotics targeting the lipid A pathway.
CAS Number
728865-23-4
Product Name Alternative
CHIR-090 | CHIR 090 | CHIR090
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL; 68.57 mM
Smiles
ONC (=O) [C@@H] (NC (=O) c1ccc (cc1) C#Cc1ccc (cc1) CN1CCOCC1) [C@@H] (C) O
Molecular Formula
C24H27N3O5
Molecular Weight
437.19
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[ (2S,3R) -3-hydroxy-1- (hydroxyamino) -1-oxobutan-2-yl]-4-[2-[4- (morpholin-4-ylmethyl) phenyl]ethynyl]benzamide

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Alternative Products

CatalogName
MBS131423CHIR-090 (CHIR 090; CHIR090)
A3307-200CHIR-090
A12365-50CHIR-090 50mg
A12365-500CHIR-090 500mg
A12365-25CHIR-090 25mg
A12365-10CHIR-090 10mg
A12365-5CHIR-090 5mg
HY-15460R-01CHIR-090 (Standard)
A12365-100CHIR-090 100mg

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