Products for Research Use Only
RegisterLogin

CHIR-124

CAT: 0013-GTR19171929-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19171929-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CHIR-124 is a potent and selective inhibitor of Chk1 (IC50: 0.3 nM), exhibiting over 2,000-fold selectivity against Chk2 and minimal activity against Cdc2 and CDK2/4. This small molecule is a valuable research tool for studying DNA damage response pathways in both cellular and animal models of cancer.
CAS Number
405168-58-3
Product Name Alternative
Cluster of differentiation antigen 135, CHIR 124, CHIR124, CHIR-124, Chk1, Checkpoint Kinase (Chk), CD135, Apoptosis, inhibit, Fms like tyrosine kinase 3, Fyn, FLT3, GSK3, GSK-3, Inhibitor, PDGFR, Platelet-derived growth factor receptor
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
96.33% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.19 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:15 mg/mL (35.72 mM)
Smiles
Clc1ccc2[nH]c (=O) c (-c3nc4ccccc4[nH]3) c (N[C@@H]3CN4CCC3CC4) c2c1
Molecular Formula
C23H22ClN5O
Molecular Weight
419.91
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Chir-124

CHIR-124 is a potent inhibitor of Chk1 that potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.

CAS Number405168-58-3
PubChem CID135399748
IUPAC Name4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1H-benzimidazol-2-yl)-6-chloro-1H-quinolin-2-one
Molecular FormulaC23H22ClN5O
Molecular Weight419.9
XLogP3.5
Topological Polar Surface Area73.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity720
SMILES
C1CN2CCC1[C@@H](C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5
InChI
InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(H2,25,28,30)/t19-/m1/s1
InChIKey
MOVBBVMDHIRCTG-LJQANCHMSA-N
Chemical Structure
2D Structure
2D structure of Chir-124
CAS: 405168-58-3
CID: 135399748
Formula: C23H22ClN5O
MW: 419.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight419.9
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass419.1512880
Monoisotopic Mass419.1512880
Topological Polar Surface Area73.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity720
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19195095CHIR-21208
GTR19195094CHIR-29498
GTR19195225-01CHIR 98024
GTR19195093CHIR-98023
GTR19173688-01CHIR-98014
GTR19160259-01CHIR-090
GTR19173962-01CHIR-99021
GTR19170958-01CHIR-090
GTR19162492-01CHIR-99021
GTR19162491-01CHIR-98014

Alternative Products

CatalogName
A8394-50CHIR-124
444297-01CHIR 124

Popular Products