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CHIR-99021 HCl

CAT: 0931-T2310L-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T2310L-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1797989-42-4
Target
GSK-3, Autophagy, Wnt/beta-catenin
Related Pathways
PI3K/Akt/mTOR signaling, Stem Cells, Autophagy, Cytoskeletal Signaling
Purity
0.9844
Bioactivity
CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivity over CDC2, ERK2, and other protein kinases. Additionally, CHIR-99021 HCl serves as a robust activator of the Wnt/β-catenin signaling pathway. Moreover, it exhibits the ability to enhance self-renewal in both mouse and human embryonic stem cells. Furthermore, CHIR-99021 HCl induces autophagy [1] [2] [3].
Smiles
Cl.N#CC1=CN=C(C=C1)NCCNC=2N=CC(C3=NC=C(N3)C)=C(N2)C=4C=CC(Cl)=CC4Cl
Molecular Formula
C22H19Cl3N8
Molecular Weight
501.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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