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RG-108

CAT: 0013-GTR19173387-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173387-01Size:5 mg
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Description
RG108 (N-Phthalyl-L-tryptophan) is a potent and cell-permeable inhibitor of DNA methyltransferases with an IC50 of 115 nM. It is widely used in epigenetic research to reactivate silenced genes and has been applied in both cellular and animal studies to investigate DNA methylation's role in development and disease.
CAS Number
48208-26-0
Product Name Alternative
N-Phthalyl-L-tryptophan
Field of Research
Epigenetics & Chromatin, Neuroscience, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
DNA methyltransferase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml) .
Smiles
[C@H] (CC=1C=2C (NC1) =CC=CC2) (C (O) =O) N3C (=O) C=4C (C3=O) =CC=CC4
Molecular Formula
C19H14N2O4
Molecular Weight
334.34
Storage Conditions
RT
Notes
For research use only.
Other Product Names
(S) -2- (1,3-dioxoisoindolin-2-yl) -3- (1H-indol-3-yl) propanoic acid

Chemical Information

RG108

DNA Methyltransferase Inhibitor is any substance that inhibits DNA methyltransferase, an enzyme required for DNA methylation. Inhibition of DNA methyltransferase results in hypomethylation of genomic DNA and cell cycle arrest at S-phase. Hypomethylation in malignant cells may also restore suppressor gene expression and re-establish controlled growth and differentiation.

CAS Number48208-26-0
PubChem CID344265
IUPAC Name2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
Molecular FormulaC19H14N2O4
Molecular Weight334.3
XLogP2.6
Topological Polar Surface Area90.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity554
SMILES
C1=CC=C2C(=C1)C(=O)N(C2=O)C(CC3=CNC4=CC=CC=C43)C(=O)O
InChI
InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)
InChIKey
HPTXLHAHLXOAKV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of RG108
CAS: 48208-26-0
CID: 344265
Formula: C19H14N2O4
MW: 334.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight334.3
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass334.09535693
Monoisotopic Mass334.09535693
Topological Polar Surface Area90.5 Ų
Heavy Atom Count25
Formal Charge0
Complexity554
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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