RG-12525

• CAS Number :

  120128-20-3

• Target :

  PPAR|||Cytochromes P450|||Leukotriene Receptor

• Related Pathways :

  Metabolism|||GPCR/G Protein|||DNA Damage/DNA Repair

• Purity :

  0.9677

• Bioactivity :

  RG-12525 (NID 525) is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guinea pig thin-walled bands, with IC50 values of 2.6 nM, 2.5 nM, and 7 nM, respectively.RG-12525 inhibits CYP3A4, with a Ki value of 0.5 µM. RG-12525 is a novel and potent PPAR-? agonist (IC50 value of about 60 nM) with species specificity for the study of asthma.

• Smiles :

  N1=NNC(=N1)CC=2C=CC=CC2COC3=CC=C(OCC4=NC=5C=CC=CC5C=C4)C=C3

• Molecular Formula :

  C25H21N5O2

• Molecular Weight :

  423.47

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C