RG-12525

CAT: 0931-T16739-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T16739-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
120128-20-3
Target
PPAR|||Cytochromes P450|||Leukotriene Receptor
Related Pathways
Metabolism|||GPCR/G Protein|||DNA Damage/DNA Repair
Purity
0.9677
Bioactivity
RG-12525 (NID 525) is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guinea pig thin-walled bands, with IC50 values of 2.6 nM, 2.5 nM, and 7 nM, respectively.RG-12525 inhibits CYP3A4, with a Ki value of 0.5 µM. RG-12525 is a novel and potent PPAR-? agonist (IC50 value of about 60 nM) with species specificity for the study of asthma.
Smiles
N1=NNC(=N1)CC=2C=CC=CC2COC3=CC=C(OCC4=NC=5C=CC=CC5C=C4)C=C3
Molecular Formula
C25H21N5O2
Molecular Weight
423.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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