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TYK2-IN-12

CAT: 0804-HY-150720-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150720-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TYK2-IN-12 (compound 30) is an orally active, potent and selective TYK2 (tyrosine kinase 2) inhibitor, with a Ki of 0.51 nM. TYK2-IN-12 inhibits IL-12 induced IFNγ, with IC50 values of 2.7 and 7.0 μM in human and mouse whole blood, respectively. TYK2-IN-12 can be used for psoriasis research[1].
CAS Number
2244061-66-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
IFNAR; JAK
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tyk2-in-12.html
Purity
98.81
Solubility
DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC=CC(F)=C1C2=NC(CN3)=C(C(NC4=CC=C(C(N5CCCC5)=O)C=C4)=C2)C3=O
Molecular Formula
C24H20F2N4O2
Molecular Weight
434.44
Precautions
H302, H315, H319
References & Citations
[1]Leit S, et al. Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg Med Chem Lett. 2022 Jul 13;73:128891.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2; JAK3; Tyk2

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