TYK2-IN-12

• CAS Number:

  2244061-66-1

• UNSPSC Description:

  TYK2-IN-12 (compound 30) is an orally active, potent and selective TYK2 (tyrosine kinase 2) inhibitor, with a Ki of 0.51 nM. TYK2-IN-12 inhibits IL-12 induced IFNγ, with IC50 values of 2.7 and 7.0 μM in human and mouse whole blood, respectively. TYK2-IN-12 can be used for psoriasis research[1].

• Target Antigen:

  IFNAR; JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tyk2-in-12.html

• Solubility:

  DMSO : 7.14 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  FC1=CC=CC(F)=C1C2=NC(CN3)=C(C(NC4=CC=C(C(N5CCCC5)=O)C=C4)=C2)C3=O

• Molecular Weight:

  434.44

• References & Citations:

  [1]Leit S, et al. Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorg Med Chem Lett. 2022 Jul 13;73:128891.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported