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T-0632

CAT: 0804-HY-19261-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19261-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T-0632 is a CCK A receptor antagonist that exhibits significant pharmacological properties in in vitro studies. T-0632 competitively inhibits the binding of [125I]CCK-8 to rat pancreatic CCK A receptors with a K_i value of 0.24 nM, which is significantly lower than the K_i value for guinea pig CCK B receptors. T-0632 has higher selectivity in inhibiting CCK-8-stimulated pancreatic enzyme release, with an IC_50 value of 5.0 nM, which is more advantageous than L-364,718 and loxiglumide. In rabbit gallbladder smooth muscle, the antagonistic effects of T-0632 and loxiglumide are reversible, while L-364,718 shows a persistent inhibitory effect. These results indicate that T-0632 is a highly potent, reversible and more selective CCK A receptor antagonist.
CAS Number
169042-78-8
UNSPSC
12352005
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/t-0632.html
Purity
99.88
Smiles
O=C(O[Na])CC[C@@]1(NC(C2=CC3=C(C=N2)C=CC=C3)=O)C(N(C4=CC=CC=C4F)C5=C1C=CC(OC)=C5)=O
Molecular Formula
C28H21FN3NaO5
Molecular Weight
521.47
References & Citations
[1]Pharmacological profile of T-0632, a novel potent and selective CCK A receptor antagonist, in vitro
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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