Products for Research Use Only
RegisterLogin

Ono 3307 (free base)

CAT: 0804-HY-167924Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-167924Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ono 3307 Free base is a novel synthetic protease inhibitor that exhibits protective effects against acute pancreatitis by preventing hyperamylasemia and pancreatic edema. Ono 3307 Free base also inhibits the redistribution of lysosomal enzymes in acinar cells and mitigates lactic dehydrogenase discharge. Ono 3307 Free base effectively reduces cathepsin B leakage from lysosomes in a dose-dependent manner. Ono 3307 Free base is able to target trypsin (Ki=48 nM), thrombin (Ki=0.18 μM), plasma kallikrein (Ki=0.29 μM), plasmin (Ki=0.31 μM), pancreatic kallikrein (Ki=3.6 μM), and chymotrypsin (Ki=47 μM) .
CAS Number
76472-28-1
UNSPSC
12352005
Target
Kallikrein; Ser/Thr Protease; Thrombin
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ono-3307-free-base.html
Smiles
O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(S(=O)(N)=O)C=C2
Molecular Formula
C14H14N4O4S
Molecular Weight
334.35
References & Citations
[1]Protection by a new synthetic protease inhibitor, ONO3307, of the rat exocrine pancreas during acute edematous pancreatitis induced by a supramaximal dose of caerulein in comparison with FOY007|[2]Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-19101-01ONO-3307
HY-109118Masupirdine (free base)
HY-152852-01Mefatinib (free base)
HY-19651-01Zanapezil (free base)
HY-116031ATC0175 (free base)
HY-120421SW116 (free base)
HY-139806SRA880 (free base)
HY-100444-01SIS3 (free base)
HY-116565A-01Usmarapride (free base)
HY-125741-01GW768505A (free base)

Alternative Products

CatalogName
GTR19211219-01Ono 3307 Free Base
TB0954TMB free base
A8893-10Rucaparib (free base)
FX56092-01Xylazine - free base
T-8100-01Tryptamine, free base
XN175452-01Norharman - free base
MBS5779607Amidantel free base
533249ML355 free base
414310Neamine Free Base
596942Carnosine free base

Popular Products