L-Ascorbic acid-13C-1

• Description:

  L-Ascorbic acid-13C-1 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen

• Product Name Alternative:

  L-Ascorbate-13C-1; Vitamin C-13C-1

• UNSPSC:

  12352005

• Target:

  Apoptosis; Calcium Channel; Endogenous Metabolite; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/l-ascorbic-acid-13c-1.html

• Purity:

  99.90

• Solubility:

  10 mM in DMSO

• Smiles:

  OC[C@@H] ([C@]1 ([H]) C (O) =[13C] (C (O1) =O) O) O

• Molecular Formula:

  C5 13CH8O6

• Molecular Weight:

  177.12

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22 (1) :18-35.; Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  178101-89-8