EB-3D

CAT: 0804-HY-115463-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-115463-01Size:5 mg
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Description
EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity[1][2][3].
CAS Number
[1839150-63-8]
Product Name Alternative
(±)-CI-952, MKS 492
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eb-3d.html
Concentration
10mM
Purity
99.64
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 9.09 mg/mL
Smiles
CN(C1=CC=[N+](CC2=CC=C(OCCOC3=CC=C(C[N+]4=CC=C(N(C)C)C=C4)C=C3)C=C2)C=C1)C.[Br-].[Br-]
Molecular Formula
C30H36Br2N4O2
Molecular Weight
644.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Mariotto E, et al. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. Biochem Pharmacol. 2018 Sep;155:213-223.|[2]Sola-Leyva A, et al. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells. Sci Rep. 2019 Mar 25;9 (1) :5109.|[3]Schiaffino-Ortega S, et al. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1) .|[4]Mariotto E, et al. Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer. Cancers (Basel) . 2018;10 (10) :391. Published 2018 Oct 22.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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