EB-3D

• Description:

  EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity[1][2][3].

• Product Name Alternative:

  (±)-CI-952, MKS 492

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  AMPK; Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/eb-3d.html

• Concentration:

  10mM

• Purity:

  99.64

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 9.09 mg/mL

• Smiles:

  CN(C1=CC=[N+](CC2=CC=C(OCCOC3=CC=C(C[N+]4=CC=C(N(C)C)C=C4)C=C3)C=C2)C=C1)C.[Br-].[Br-]

• Molecular Formula:

  C30H36Br2N4O2

• Molecular Weight:

  644.44

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Mariotto E, et al. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. Biochem Pharmacol. 2018 Sep;155:213-223.|[2]Sola-Leyva A, et al. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells. Sci Rep. 2019 Mar 25;9 (1) :5109.|[3]Schiaffino-Ortega S, et al. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1) .|[4]Mariotto E, et al. Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer. Cancers (Basel) . 2018;10 (10) :391. Published 2018 Oct 22.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1839150-63-8]